Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Local hyperadrenergic states after a random flap elevation mediated by humoral vasoconstrictors can lead to necrosis. This study aimed evaluate the effect of Botulinum Toxin A (BoNT-A) on reducing levels Norepinephrine (NE) as main vasoactive substance, well its additive with Vascular Endothelial Growth Factor (VEGF) in increasing viability flap. 28 Wistar Rats Caudally Based Modified McFarlane Flap were divided into four groups. Group I received BoNT-A 3 days before elevation, group II VEGF immediately III combination and VEGF, IV was control group. Result this NE lowest found BoNT-A+VEGF (94.63 ± 5 .25 ng/ml, p<0.05 I, p<0.01 groups IV). The highest value FVR shown (93.37 2.19 %, p < 0.05 0.01 Meanwhile, increase not statistically significant. So Conclusion administration flaps decreasing levels.